Experiencia argentina del uso compasivo de osimertinib

José N. Minatta; Lorena Lupinacci; Gonzalo Recondo; Susana Sena; Gastón Boggio; Alejandro Muggeri; Carlos Rosenbrock; Federico Cayol; Martín Ángel; Miguel Muñoz; Susana Berutti; Nicolás Castagneris; Dolores Gómez Bradley; José M. Lastiri

doi:10.56969/oc.v23i2.57

Autores/as

José N. Minatta Hospital Italiano, Buenos Aires https://orcid.org/0000-0002-3531-1920
Lorena Lupinacci Sección Oncología, Hospital Italiano de Buenos Aires
Gonzalo Recondo Servicio de Oncología, CEMIC, Buenos Aires
Susana Sena Hospital Alemán, Buenos Aires https://orcid.org/0000-0002-4511-6395
Gastón Boggio Sanatorio Parque, Rosario, Santa Fe
Alejandro Muggeri FLENI, Buenos Aires
Carlos Rosenbrock CEMO, Paraná, Entre Ríos
Federico Cayol Sección de Oncología Clínica, Hospital Italiano de Buenos Aires https://orcid.org/0000-0001-9794-2173
Martín Ángel Instituto Alexander Fleming, Buenos Aires https://orcid.org/0000-0002-1463-8887
Miguel Muñoz Oncología, Rosario, Santa Fe
Susana Berutti Hospital Italiano de La Plata, Buenos Aires
Nicolás Castagneris Clínica Sucre, Córdoba
Dolores Gómez Bradley Sección Oncología, Hospital Italiano de Buenos Aires
José M. Lastiri Hospital Italiano, Buenos Aires

DOI:

https://doi.org/10.56969/oc.v23i2.57

Palabras clave:

osimertinib, cáncer de pulmón, mutaciones, receptor del factor de crecimiento epidérmico, lung cancer, mutations, epidermal growth factor receptor

Resumen

El osimertinib es un inhibidor irreversible de tercera generación de tirosina quinasa (ITK) del receptor del factor de crecimiento epidérmico (EGFR), y de la mutación de resistencia T790M del EGFR. Está indicado para el tratamiento de primera línea de pacientes con cáncer de pulmón no microcítico metastásico cuyos tumores tienen deleciones del exón 19 del EGFR o mutaciones L858R del exón 21.

También está indicado para el tratamiento de pacientes con cáncer de pulmón de células no pequeñas (CPCNP) metastásico con mutación detectable de T790M, cuya enfermedad ha progresado durante el tratamiento con inhibidores de tirosina quinasa EGFR (TKI).

Evaluamos la seguridad y eficacia de osimertinib en el uso compasivo de pacientes diagnosticados con cáncer de pulmón avanzado, con mutación de EGFR y que progresaron a terapia previa con inhibidores de tirosina quinasa y en el momento de la progresión presentaban la mutación de resistencia T790m y/o tenían esta mutación de novo.

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